催化作用
组合化学
化学
表面改性
氧化还原
基质(水族馆)
芳基
偶联反应
有机化学
纳米技术
材料科学
海洋学
地质学
物理化学
烷基
作者
Gerald B. Hammond,Sagar R. Mudshinge,Yuhao Yang,Bo Xu,Zhichao Lu
标识
DOI:10.1002/anie.202115687
摘要
The first C-SCF3 /SeCF3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3 or Me4 NSeCF3 , and organohalides as substrates are reported. The new methodology enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers with a broad substrate scope (>60 examples with up to 97 % isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive molecules, which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochemical research and development.
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