ASYMMETRIC ACID ORGANOCATALYSIS

Chiral acid organocatalysts including hydrogen bond catalysts and chiral Brønsted acids surged after 2000. Recent progress in the chiral Brønsted acid catalysis mainly after 2010 is discussed, focusing on relatively stronger Brønsted acids such as chiral phosphoric acid derived from binaphthol, and their analogues. Transformation mediated by chiral Brønsted acid is organized by the type of reactions: nucleophilic reaction, cycloaddition reaction, Michael addition reaction, reduction, addition to alkenes, substitution, rearrangement, and others.