Engineered Probiotics: Applications and Biological Containment
合成生物学
计算生物学
生物
生物技术
作者
Babasola Sola-Oladokun,Eamonn P. Culligan,Rolf Backofen
出处
期刊:Annual review of food science and technology [Annual Reviews] 日期:2017-02-28卷期号:8 (1): 353-370被引量:35
标识
DOI:10.1146/annurev-food-030216-030256
摘要
Bioengineered probiotics represent the next generation of whole cell–mediated biotherapeutics. Advances in synthetic biology, genome engineering, and DNA sequencing and synthesis have enabled scientists to design and develop probiotics with increased stress tolerance and the ability to target specific pathogens and their associated toxins, as well as to mediate targeted delivery of vaccines, drugs, and immunomodulators directly to host cells. Herein, we review the most significant advances in the development of this field. We discuss the critical issue of biological containment and consider the role of synthetic biology in the design and construction of the probiotics of the future.