The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells

RUNX1-ETO, the t(8;21)-derived fusion protein, is a recurrent somatic lesion detected in approximately 12% of de novo acute myeloid leukemia (AML) and up to 40% of M2 subtype AML at diagnosis. RUNX...