The human lung lipidome mirrors histopathological phenotypes of lung tissues

Lipid metabolism is closely connected to respiratory functions. Especially, pulmonary surfactant is constantly synthesized, stored, and secreted by type II pneumocytes located in the alveoli. Disruption of this metabolism affects lung functions in a not yet well characterized manner. To gain insight into these fundamental physiological processes, we present a systematic lipidomics study of 43 human lung tissue samples from 26 lung-cancer patients.