多糖
血红蛋白
贫血
化学
免疫系统
铁蛋白
红细胞压积
薯蓣属
脾脏
红细胞
红细胞
免疫学
生物化学
药理学
传统医学
生物
医学
内分泌学
内科学
病理
替代医学
作者
Yun Zhang,Fuqiu Ma,Jing Zhu,Zuliang Du,Ying-Yong Zhao,Xiuhua Li
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2017-11-07
卷期号:17 (17)
被引量:9
标识
DOI:10.2174/1389557517666170424130327
摘要
Objective: Dioscorea opposita Thunb is the famous food and traditional medicine in China and it was rich in polysaccharides. Polysaccharides of Dioscorea Opposita Thunb possess immunoregulatory activity, free radical scavenging activity and anti-diabetic activity. A novel polysaccharide- iron(III) complex (CYPIC) was synthesized by using crude polysaccharide extracted from Dioscorea opposita Thunb. The component, structure, morphology and molecular weights of CYPIC were analysed, and the anti-anemia, acute toxicity and nonspecific immune regulating activities of CYPIC were assayed. The results showed that CYPIC could increase red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT), thymus and spleen index of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms of CYPIC should be further studied, CYPIC has the potential to be used as an iron supplement for the treatment of iron deficiency anemia. Conclusion: The large scale industrial production was suggested due to the simple preparation processing of CYPIC. Keywords: Dioscorea opposita Thunb, iron deficiency anemia, iron supplement, polysaccharide, polysaccharide-iron(III) complex.
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