32.3.1.3 1,2-Dihaloalkenes (Update 2014)

Abstract The present chapter is an update to the earlier Science of Synthesis contribution Section 32.3.1 (written by Nubbemeyer in 2008) describing general synthetic methods to access 1,2-dihaloalkenes. It focuses on new synthetic developments for this rather broad class of compounds, covering the literature from 2005 until the end of 2013. Some exceptions from before 2005 are included if they are of current interest and are not covered in the original contribution. Due to the vast number of examples in the literature, the current overview does not include methods where new compounds with 1,2-dihaloalkene units are formed from compounds with the same 1,2-dihaloalkene unit through side-chain manipulations. The focus is on synthetic methods that are capable of newly creating the title 1,2-dihalogenated alkene moiety. The update does not include halogenations of aromatics or heteroaromatics.