Lossen rearrangement by Rh(iii)-catalyzed C–H activation/annulation of aryl hydroxamates with alkynes: access to quinolone-containing amino acid derivatives

An efficient access to new CF 3 -containing 2-quinolones has been developed via Rh( iii )-catalyzed C–H activation/Lossen rearrangement/annulation cascade of N -pivaloyloxy-arylamides with internal alkynes bearing α-CF 3 -α-amino acid moiety on triple bond.