Modification of Metal-Organic Framework Nanoparticles Using Dental Pulp Mesenchymal Stem Cell Membranes to Target Oral Squamous Cell Carcinoma

Engineering a targetable nanoparticle to tumor cell is a challenge issue for clinical application. Our results demonstrated that the chemokine CXCL8 secreted by oral squamous cell carcinoma (OSCC) could act as a chemoattractant to attract dental pulp mesenchymal stem cell (DPSC), which expressed the CXCL8 binding receptor, CXCR2, to the OSCC. Therefore, to create OSCC targetable nanoparticles, we used DPSC membranes to modify nanoparticles of metal-organic framework nanoparticles (MOFs) resulting in a novel [email protected] nanoparticle. Interestingly, results from in vitro and in vivo experiments illustrated that [email protected] possessed specificity for the OSCC, and the [email protected] carried DOX (doxorubicin), [email protected] could induce CAL27 cell death in vitro and block CAL27 tumor growth in vivo. Our data suggest that this novel [email protected] nanoparticle is a potential targetable drug delivery system for the OSCC in the future clinical application.