结直肠癌
生物
血小板
生物标志物
核糖核酸
癌症
小RNA
接收机工作特性
癌症研究
免疫学
生物信息学
肿瘤科
内科学
基因
遗传学
医学
作者
Bingqi Ye,Fengying Li,Mengsha Chen,Yu Weng,Chao Qi,Yulin Xie,Qikun Zhang,Huisi Ding,Jun Zhang,Xiangwei Gao
出处
期刊:Genomics
[Elsevier]
日期:2022-01-01
卷期号:114 (1): 31-37
被引量:17
标识
DOI:10.1016/j.ygeno.2021.11.026
摘要
Evidence has suggested the potential of tumor-educated platelets as a biomarker trove for cancer diagnostics, but the difficulty in isolation limits its application. Since most of the circulating RNAs are derived from platelets, the change of RNA profile in platelets may lead to altered RNA expression in serum. Here, we identified a panel of platelet-associated long non-coding RNAs (lncRNAs) and evaluated its diagnostic capacity in serum of colorectal cancer (CRC) patients. Four lncRNAs, LNCAROD, SNHG20, LINC00534, and TSPOAP-AS1, were upregulated in both platelets and serum of CRC patients. A binary logistic model derived from them has validated area under roc curve of 0.78 indicating great performance. Furthermore, the expression levels of LNCAROD and TSPOAP-AS1 were correlated with cancer staging and tumor location. Together, our results add novel lncRNA biomarkers to the list of blood tests for CRC diagnostics and provide molecular evidence for the cross-talk between CRC platelets and serum.
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