信使核糖核酸
淀粉样前体蛋白
分子生物学
蛋白酶
生物
阿尔茨海默病
基因表达
脑组织
蛋白酶抑制剂(药理学)
核糖核酸酶
生物化学
细胞生物学
化学
核糖核酸
基因
酶
疾病
内科学
免疫学
医学
神经科学
病毒载量
抗逆转录病毒疗法
人类免疫缺陷病毒(HIV)
作者
Seigo Tanaka,Satoshi Shiojiri,Yasuyuki Takahashi,Nobuya Kitaguchi,Hirataka Ito,Masakuni Kameyama,Jun Kimura,Shotaro Nakamura,Kunihiro Ueda
标识
DOI:10.1016/0006-291x(89)92760-5
摘要
Expression of three types of mRNA encoding amyloid β-protein precursor (APP) in various tissues was analysed, using a ribonuclease protection assay, with special reference to Alzheimer's disease (AD). The total content and the proportion of APP mRNAs were specific to each tissue. Among eight tissues examined, the brain was distinct in that the expression level was highest and APP695 mRNA was expressed in abundance. The ratio of APP770/APP751/APP695 mRNAs was approximately 1:10:20 in the cerebral cortex of control brain. The proportions of APP770 mRNA and APP770-plus-APP751 mRNAs increased up to 2.6- and 1.4-fold, respectively, in various regions of AD brain compared with control. The enhanced expression of protease inhibitor-haboring types (APP770 and APP751) may disturb the balance between biosynthesis and degradation of APPs and ultimately lead to accumulation of β-protein as amyloid.
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