链脲佐菌素
坐骨神经
MAPK/ERK通路
内分泌学
内科学
医学
神经损伤
免疫组织化学
糖尿病
激酶
细胞外
雪旺细胞
解剖
生物
麻醉
细胞生物学
作者
Lena Stenberg,Martin Kanje,Lisa Mårtensson,Lars B. Dahlin
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2011-01-26
卷期号:22 (2): 73-77
被引量:10
标识
DOI:10.1097/wnr.0b013e328342986c
摘要
Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats.
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