神经保护
神经学
缺血
激酶
炎症
神经科学
限制
冲程(发动机)
医学
生物
细胞生物学
内科学
机械工程
工程类
作者
Dirk A. Ridder,Markus Schwaninger
标识
DOI:10.1016/j.expneurol.2012.09.010
摘要
TGFβ-activated kinase 1 (TAK1), a MAP3 kinase, is involved in at least five signaling cascades that modulate ischemic brain damage. Inhibition of TAK1 may therefore be an efficient way to interfere with multiple mechanisms in ischemic stroke. Indeed, a recent publication in Experimental Neurology confirmed that TAK1 inhibition by 5Z-7-oxozeaenol is neuroprotective. The beneficial effect of 5Z-7-oxozeaenol was associated with a reduced activation of Jun kinase that leads to inflammation and apoptosis. Recently, other TAK1 inhibitors were developed suggesting that TAK1 may prove as an efficient therapeutic target for neurodegenerative diseases if safety issues are not limiting.
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