The CREB transcription factor and processes of memory formation

The CREB protein (cyclic AMP response element-binding protein) is a well studied and important transcription factor. Current experimental data suggest that CREB-dependent gene expression plays a critical role in the development and functioning of the nervous system. In this review, we considered aspects of the functioning of CREB-regulated gene expression, such as the structures of proteins of the CREB family, mechanisms of activation of CREB-dependent transcription and intracellular pathways of its regulation, and the role of CREB in learning and memory formation.