医学
祖细胞
内皮祖细胞
心脏病学
内皮干细胞
内科学
干细胞
细胞生物学
体外
生物化学
生物
化学
作者
Caroline Schmidt-Lucke,Lothar Rössig,Stephan Fichtlscherer,Mariuca Vasa,Martina Britten,Ulrike Kämper,Stefanie Dimmeler,Andreas M. Zeiher
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:2005-06-07
卷期号:111 (22): 2981-2987
被引量:1054
标识
DOI:10.1161/circulationaha.104.504340
摘要
The maintenance of endothelial integrity plays a critical role in preventing atherosclerotic disease progression. Endothelial progenitor cells (EPCs) were experimentally shown to incorporate into sites of neovascularization and home to sites of endothelial denudation. Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium.In 120 individuals (43 control subjects, 44 patients with stable coronary artery disease, and 33 patients with acute coronary syndromes), circulating EPCs were defined by the surface markers CD34+KDR+ and analyzed by flow cytometry. Cardiovascular events (cardiovascular death, unstable angina, myocardial infarction, PTCA, CABG, or ischemic stroke) served as outcome variables over a median follow-up period of 10 months. Patients suffering from cardiovascular events had significantly lower numbers of EPCs (P<0.05). Reduced numbers of EPCs were associated with a significantly higher incidence of cardiovascular events by Kaplan-Meier analysis (P=0.0009). By multivariate analysis, reduced EPC levels were a significant, independent predictor of poor prognosis, even after adjustment for traditional cardiovascular risk factors and disease activity (hazard ratio, 3.9; P<0.05).Reduced levels of circulating EPCs independently predict atherosclerotic disease progression, thus supporting an important role for endogenous vascular repair to modulate the clinical course of coronary artery disease.
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