材料科学
激光器
温度测量
图像分辨率
光学
分辨率(逻辑)
生物医学工程
光电子学
计算机科学
物理
医学
量子力学
人工智能
作者
Kirill V. Larin,Irina V. Larina,Massoud Motamedi,Rinat O. Esenaliev
摘要
To improve the safety and efficacy of thermal therapy, it is often necessary to map tissue temperature in real time with submillimeter spatial resolution in order to accurately control the boundaries of heated regions and minimize thermal damage to surrounding normal tissues. Current imaging modalities fail to monitor tissue temperature in real time with high resolution and accuracy. We propose to use optoacoustic techniques for accurate, real-time monitoring of tissue temperature with high spatial resolution. Our previous studies demonstrated that the efficiency of optoacoustic wave generation in tissues increases linearly with temperature during uniform heating. In this study, we induced temperature gradients in treated samples and monitor temperature distribution in tissue using optoacoustic technique. Fundamental harmonic of Q-switched Nd:YAG laser was used for optoacoustic wave generation and probing of tissue temperature while the tissue temperature was also monitored with a multisensor temperature probe inserted in the samples. Good agreement between optoacoustic dat and the tissue temperature as recorded via the probe was demonstrated. The optoacoustic techniques was capable of real-time temperature distribution monitoring with submillimeter resolution and high accuracy.
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