医学
荟萃分析
经皮冠状动脉介入治疗
传统PCI
内科学
心肌梗塞
随机对照试验
急诊医学
心脏病学
置信区间
科克伦图书馆
梅德林
狼牙棒
优势比
危险系数
作者
Alessandro Spirito,Giuseppe Gargiulo,George C.M. Siontis,Andreas Mitsis,Michael Billinger,Stephan Windecker,Marco Valgimigli
出处
期刊:Eurointervention
[Europa Digital and Publishing]
日期:2021-02-05
卷期号:16 (15)
被引量:1
标识
DOI:10.4244/eij-d-20-00221
摘要
Aims The aim of this meta-analysis was to appraise the burden of cardiovascular mortality and morbidity among patients undergoing percutaneous coronary intervention (PCI) after out-of-hospital cardiac arrest (OHCA). Methods and results This was a meta-analysis of studies assessing the cardiovascular mortality or at least one other pre-defined outcome in OHCA patients undergoing PCI. Forty-nine studies with a total of 301,902 patients (73,634 OHCA and 228,268 non-OHCA patients) were included. Compared to non-OHCA patients, all-cause mortality was higher in OHCA patients (29% vs 4%). The cause of 39% of deaths among OHCA patients was cardiovascular: PCI was more frequently unsuccessful (9.2% vs 7.6%) and there were higher rates of stent thrombosis (2.9% vs 0.8%), myocardial infarction (1.7% vs 1.4%), relevant bleeding (10.2% vs 2.1%) and stroke (1.7% vs 0.5%). OHCA patients compared to non-OHCA patients had a higher risk of all-cause mortality (risk ratio [RR] 6.4, 95% CI: 5.5-7.4), cardiovascular death (4.6, 1.1-19), unsuccessful coronary revascularisation (1.4, 1.1-1.7), stent thrombosis (3.8, 0.6-22.7), myocardial infarction (1.4, 1.1-1.7), relevant bleeding (3.2, 2.5-4.1) and stroke (3.1, 2.3-4.3). Conclusions Almost one third of OHCA patients undergoing PCI die and more than one third of the fatalities are attributable to cardiovascular causes. The burden of ischaemic and bleeding complications was consistently higher and the success rates of PCI lower among OHCA as compared to non-OHCA patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI