Treatment of von Willebrand's Disease

Von Willebrand's disease is an inherited bleeding disorder with a prevalence as high as 1 to 2 percent in the general population, according to screening studies. However, its prevalence is deemed to be only 30 to 100 cases per million on the basis of symptomatic referrals, a prevalence that is similar to that of hemophilia A. This article discusses major advances in our understanding of the pathophysiology, molecular basis, and management of von Willebrand's disease.