生物
免疫
髓系细胞
先天免疫系统
髓样
封锁
疾病
癌症
败血症
免疫系统
免疫学
医学
遗传学
内科学
受体
作者
Berk Aykut,Ruonan Chen,Jacqueline I. Kim,Dongling Wu,Sorin A. A. Shadaloey,Raquel Abengozar,Pamela Preiss,Anjana Saxena,Smruti Pushalkar,Joshua Leinwand,Brian Diskin,Wei Wang,Gregor Werba,Matthew E. Berman,Steve Ki Buom Lee,Alireza Khodadadi‐Jamayran,Deepak Saxena,William A. Coetzee,George Miller
出处
期刊:Science immunology
[American Association for the Advancement of Science]
日期:2020-08-14
卷期号:5 (50)
被引量:147
标识
DOI:10.1126/sciimmunol.abb5168
摘要
is regulated via up-regulation of histone deacetylase 2. Collectively, our work uncovers Piezo1 as a targetable immune checkpoint that drives immunosuppressive myelopoiesis in cancer and infectious disease.
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