免疫疗法
免疫原性细胞死亡
免疫系统
恶性肿瘤
医学
癌症免疫疗法
癌症
程序性细胞死亡
免疫学
效应器
抗原
癌细胞
嵌合抗原受体
癌症研究
细胞凋亡
生物
内科学
生物化学
作者
Sihui Yu,Hongyang Xiao,Li Ma,Jiawen Zhang,Jiarong Zhang
标识
DOI:10.1016/j.bbcan.2023.188946
摘要
Immunogenic cell death (ICD) has been a revolutionary modality in cancer treatment since it kills primary tumors and prevents recurrent malignancy simultaneously. ICD represents a particular form of cancer cell death accompanied by production of damage-associated molecular patterns (DAMPs) that can be recognized by pattern recognition receptors (PRRs), which enhances infiltration of effector T cells and potentiates antitumor immune responses. Various treatment methods can elicit ICD involving chemo- and radio-therapy, phototherapy and nanotechnology to efficiently convert dead cancer cells into vaccines and trigger the antigen-specific immune responses. Nevertheless, the efficacy of ICD-induced therapies is restrained due to low accumulation in the tumor sites and damage of normal tissues. Thus, researchers have been devoted to overcoming these problems with novel materials and strategies. In this review, current knowledge on different ICD modalities, various ICD inducers, development and application of novel ICD-inducing strategies are summarized. Moreover, the prospects and challenges are briefly outlined to provide reference for future design of novel immunotherapy based on ICD effect.
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