Neuroplasticity: The Critical Issue for Alzheimer's Disease and Links to Obesity and Depression

In their paper, Ly et al. link obesity, Alzheimer's disease (AD), and depression, with the consideration that there are neuroinflammatory mechanisms linking these conditions, and, accordingly, there should be anti-inflammatory approaches for managing and preventing all three conditions. The primary question addressed in the discussion here is whether the bases of the established linkages between AD and obesity and depression are related to neuroinflammation, as suggested by Ly et al. paper, or whether AD is an attack on neuroplasticity, which also interacts with adiposity and depression.