细菌外膜
生物物理学
化学渗透
细菌
机制(生物学)
膜转运
膜
转运蛋白
生物
细胞生物学
化学
物理
生物化学
遗传学
ATP合酶
大肠杆菌
量子力学
基因
酶
作者
Augustinas Silale,Bert van den Berg
标识
DOI:10.1146/annurev-micro-032421-111116
摘要
TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and mediate energy-dependent uptake of molecules that are too scarce or large to be taken up efficiently by outer membrane (OM) diffusion channels. This process requires energy that is derived from the proton motive force and delivered to TBDTs by the TonB-ExbBD motor complex in the inner membrane. Together with the need to preserve the OM permeability barrier, this has led to an extremely complex and fascinating transport mechanism for which the fundamentals, despite decades of research, are still unclear. In this review, we describe our current understanding of the transport mechanism of TBDTs, their potential role in the delivery of novel antibiotics, and the important contributions made by TBDT-associated (lipo)proteins.
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