单萜
色酮
原酸酯
化学
立体化学
萜烯
甲醇
二维核磁共振波谱
有机化学
作者
Gordana Krstić,Muhammad Bello Saidu,Petra Bombicz,Sourav De,H. Abu Ali,István Zupkó,Róbert Berkecz,Umar Shehu Gallah,Dóra Rédei,Judit Hohmann
标识
DOI:10.1021/acs.jnatprod.2c01132
摘要
Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A–E (1–5), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of Centrapalus pauciflorus. Compounds 1–3 are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas 4 and 5 are dihydrochromone–monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A–E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC50 < 10 μM) in each case.
科研通智能强力驱动
Strongly Powered by AbleSci AI