氧化应激
谷胱甘肽
化学
金属
氧化损伤
氧化磷酸化
纳米技术
生物物理学
材料科学
生物化学
生物
有机化学
酶
作者
Wenting Li,Shikai Liu,Dalin He,Ruoxi Zhao,Pengyu Zang,Siyi Li,Linyang Fang,Rumin Li,Manjie Zhang,Piaoping Yang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-02-02
标识
DOI:10.1021/acs.nanolett.3c04813
摘要
Ferroptosis is a novel type of nonapoptotic programmed cell death involving the accumulation of lipid peroxidation (LPO) to a lethal threshold. Herein, we propose tunable zeolitic imidazolate framework (ZIFs)-engineered biodegradable nanozymes for ferroptosis mediated by both reactive oxygen species (ROS) and nitrogen species (RNS). l-Arginine is utilized as an exogenous nitric oxide donor and loaded into hollow ZIFs@MnO2 artificial nanozymes, which are formed by etching ZIFs with potassium permanganate and simultaneously generating a MnO2 shell in situ. The constructed nanozymes with multienzyme-like activities including peroxidase, oxidase, and catalase can release satisfactory ROS and RNS through a cascade reaction, consequently promoting the accumulation of LPO. Furthermore, it can improve the efficiency of ferroptosis through a three-step strategy of glutathione (GSH) depletion; that is, the outer MnO2 layer consumes GSH under slightly acidic conditions and RNS downregulates SLC7A11 and glutathione reductase, thus directly inhibiting GSH biosynthesis and indirectly preventing GSH regeneration.
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