五三肽重复
线粒体核糖体
生物
细胞生物学
翻译(生物学)
线粒体
信使核糖核酸
核糖体分析
eIF4A标准
线粒体DNA
细胞器生物发生
遗传学
核糖体
核糖核酸
RNA编辑
生物发生
基因
作者
Huy Cuong Tran,Virgínia M. Schmitt,Sbatie Lama,Chuande Wang,Alexandra Launay‐Avon,Katja Bernfur,Kristin Sultan,Kasim Khan,Véronique Brunaud,Arnaud Liehrmann,Benoît Castandet,Fredrik Levander,Allan G. Rasmusson,Hakim Mireau,Étienne Delannoy,Olivier Van Aken
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-09-01
卷期号:381 (6661)
被引量:4
标识
DOI:10.1126/science.adg0995
摘要
Plant mitochondria represent the largest group of respiring organelles on the planet. Plant mitochondrial messenger RNAs (mRNAs) lack Shine-Dalgarno-like ribosome-binding sites, so it is unknown how plant mitoribosomes recognize mRNA. We show that “mitochondrial translation factors” mTRAN1 and mTRAN2 are land plant–specific proteins, required for normal mitochondrial respiration chain biogenesis. Our studies suggest that mTRANs are noncanonical pentatricopeptide repeat (PPR)–like RNA binding proteins of the mitoribosomal “small” subunit. We identified conserved Adenosine (A)/Uridine (U)-rich motifs in the 5′ regions of plant mitochondrial mRNAs. mTRAN1 binds this motif, suggesting that it is a mitoribosome homing factor to identify mRNAs. We demonstrate that mTRANs are likely required for translation of all plant mitochondrial mRNAs. Plant mitochondrial translation initiation thus appears to use a protein-mRNA interaction that is divergent from bacteria or mammalian mitochondria.
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