吡啶
化学
喹啉
金属
过渡金属
烷基化
有机化学
组合化学
催化作用
作者
Ryo Tsunokawa,Yukiko Karuo,Atsushi Tarui,Kazuyuki Sato,Takamitsu Hosoya,Tomohiro Agou,Kentaro Kawai,Masaaki Omote
标识
DOI:10.1002/ejoc.202300885
摘要
Abstract We achieved metal‐free pyridine arylations via O ‐triflated pyridine N ‐oxides and N ‐alkylated indoles. The reactions proceeded through reactive intermediates, obtained upon treatment of pyridine N ‐oxides with Tf 2 O, which were sufficiently activated for preferentially installing various indoles at the nitrogen‐adjacent positions of pyridine. This protocol features mild conditions, short reaction times, and ease of handling under stirring and air at room temperature. Furthermore, no transition metal is required, which renders our procedure an environmentally benign approach to pyridine arylation.
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