光热治疗
三阴性乳腺癌
咬合
癌症研究
体内
乳腺癌
一氧化氮
联合疗法
放射治疗
癌症
医学
化学
材料科学
纳米技术
药理学
内科学
生物
生物技术
计算机图形学(图像)
计算机科学
作者
Danping Wu,Xiaoyi Chen,Shang J. Yao,Yichen He,G. Chen,Xiaojuan Hu,Chen Yang,Zhenye Lv,Jing Yu,Ketao Jin,Yu Cai,Xiaozhou Mou
出处
期刊:Small
[Wiley]
日期:2024-04-19
被引量:1
标识
DOI:10.1002/smll.202400919
摘要
Abstract Triple‐negative breast cancer (TNBC) is a highly aggressive and uncommon subtype of breast cancer with a poor prognosis. It is crucial to prioritise the creation of a nanotherapeutic method that is highly selective and actively targeting TNBC. This study explores a new nanosystem, Cu 9 S 8 ‐SNAP@PM (C‐S@P), composed of Cu 9 S 8 ‐SNAP coated with a platelet membrane (PM). The purpose of this nanosystem is to cure TNBC using multimodal therapy. The utilisation of PM‐coated nanoparticles (NPs) enables active targeting, leading to the efficient accumulation of C‐S@P within the tumour. The Cu 9 S 8 component within these NPs serves the potential to exert photothermal therapy (PTT) and chemodynamic therapy (CDT). Simultaneously, the S‐Nitroso‐N‐Acetylvanicillamine (SNAP) component enables nitric oxide (NO) gas therapy (GT). Furthermore, when exposed to NIR‐II laser light, Cu 9 S 8 not only increases the temperature of the tumour area for PTT, but also boosts CDT and stimulates the release of NO through thermal reactions to improve the effectiveness of GT. Both in vitro and in vivo experimental results validate that C‐S@P exhibits minimal side effects and represents a multifunctional nano‐drug targeted at tumors for efficient treatment. This approach promises significant potential for TNBC therapy and broader applications in oncology.
科研通智能强力驱动
Strongly Powered by AbleSci AI