犬细小病毒
先锋
病毒学
生物
抗体
细小病毒
病毒
免疫学
考古
历史
作者
Raj Packianathan,Andrew Hodge,Jacqueline D. Wright,Lynette Lavidis,Keith Ameiss,Hiu Ying Esther Yip,Malihe Akbarzadeh,Maryam Sharifian,Reza Amanollahi,Aliakbar Khabiri,Farhid Hemmatzadeh
出处
期刊:Viral Immunology
[Mary Ann Liebert]
日期:2022-10-01
卷期号:35 (8): 553-558
被引量:4
标识
DOI:10.1089/vim.2022.0027
摘要
Canine parvovirus type 2 (CPV-2) remains one of the most significant viral pathogens in dogs in Australia and worldwide despite the availability of safe and effective CPV vaccines. At least three different variants of CPV-2 have emerged and spread all around the world, namely CPV-2a, CPV-2b, and CPV-2c. The ability of the current vaccines containing either original CPV-2 type or CPV-2b variant to cross protect the heterologous variants has been well demonstrated in laboratory studies, despite some concerns regarding the vaccine efficacy against the emerging variants. Vanguard®, a series of multivalent vaccines, has been in the market for a considerable period of time and demonstrated to provide efficacy against all three types of CPV variants CPV-2a, CPV-2b, and CPV-2c. The purpose of this study was to evaluate the ability of the recently registered Vanguard C4 vaccine to induce cross-neutralizing antibodies against the Australian isolates of CPV-2a, CPV-2b, and CPV-2c variants. Blood samples collected from dogs vaccinated with Vanguard C4 were analyzed by virus neutralizing assays developed for each of three CPV variants. The results of the study demonstrated that Vanguard vaccine induced cross-neutralizing antibodies against the Australian isolates of CPV-2a, CPV-2b, and CPV-2c, thus offering cross protection against all three Australian CPV variants.
科研通智能强力驱动
Strongly Powered by AbleSci AI