Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma

, stimulating type I interferon production and eliciting systemic antitumor immunity. In vitro and in vivo studies demonstrate robust tumor suppression and prolonged survival in osteosarcoma-bearing mice. Our work proposes an innovative "ferroptosis-mtDNA-immunotherapy" paradigm, offering a promising strategy for osteosarcoma treatment.