肺癌
生物
孟德尔随机化
癌症研究
癌症
致癌物
体内
肿瘤科
DNA损伤
生物信息学
细胞周期
DNA修复
基因
分子医学
医学
肺
计算生物学
细胞生长
药理学
癌细胞
体外
肺癌的治疗
转录组
靶向治疗
毒性
作者
Yongbin Lu,Weize Kong,Kaiwen Wang,Zicong Shao,Hui Xu,Xuping Song,Siyu Zhang,Li Ma,Zhiyuan Cheng,Fei Su,Tao Zhang,Kehu Yang
标识
DOI:10.1016/j.ecoenv.2025.119087
摘要
exposure upregulated DHX34, thereby promoting lung cancer cell proliferation and tumor growth both in vitro and in vivo. Together, these findings provide multi-level evidence that DHX34 mediates Cd-induced lung cancer progression, highlighting the carcinogenic potential of environmental heavy metal exposure and offering new insights into molecular targets for early prevention, risk stratification, and therapeutic intervention.
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