Relative mRNA expression signature of PBMC-derived NLRP3 inflammasomes in progression of type 2 diabetic kidney disease

A dynamic interplay exists between DKD progression and PBMC-derived mRNA expression of NLRP3 inflammasome and HSP72. At the systemic level, while NLRP3 exasperates inflammation, the protective role of HSP72 is extinguished. Their expression patterns in circulatory immune cells are associated with eGFR decline, tying systemic inflammatory state to worsening kidney disease outcomes.