YAP1::MAML2 Fusion Positive Epithelioid Soft Tissue Neoplasms: A Case Report and Review of the Literature

In the recent literature soft tissue neoplasms which harbor a recurrent YAP1::MAML2 fusion and have anepithelioid morphology with resemblance to myxoinflammatory fibroblasticsarcoma (MIFS) have been reported. In a recent series these tumors had anodular appearance and central necrosis and were termed nodular necrotizingvariants of MIFS. But their exact relationship to MIFS and their biological behavior seem to be unclear. We report a YAP1::MAML2 fusion positive nodular and necrotizing tumor with a MIFS-like morphology and provide a review of the literature.