YAP1::MAML2 Fusion Positive Epithelioid Soft Tissue Neoplasms: A Case Report and Review of the Literature

In the recent literature soft tissue neoplasms which harbor a recurrent YAP1::MAML2 fusion and have an epithelioid morphology with resemblance to myxoinflammatory fibroblastic sarcoma (MIFS) have been reported. In a recent series these tumors had a nodular appearance and central necrosis and were termed nodular necrotizing variants of MIFS. But their exact relationship to MIFS and their biological behavior seem to be unclear. We report a YAP1::MAML2 fusion positive nodular and necrotizing tumor with a MIFS-like morphology and provide a review of the literature.