Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD

The combination of hypercholesterolemia and Ang II-induced hypertension exerts strong synergistic effects on coronary atherogenesis. This is attributable to a selective vulnerability of coronary endothelium-dependent vasodilator responses to Ang II exposure and prostaglandin inhibition. ApoE^SA/SA represents a novel and convenient mouse model of coronary atherosclerosis with spontaneous myocardial infarction.