间充质干细胞
微泡
再生(生物学)
干细胞
再生医学
旁分泌信号
细胞生物学
组织工程
生物医学工程
化学
生物
医学
小RNA
生物化学
基因
受体
作者
Yuru Tong,Weiyang Jin,Guanghua Yang
出处
期刊:PubMed
日期:2023-04-25
卷期号:39 (4): 1351-1362
标识
DOI:10.13345/j.cjb.220558
摘要
In recent years, mesenchymal stem cell (MSCs)-derived exosomes have attracted much attention in the field of tissue regeneration. Mesenchymal stem cell-derived exosomes are signaling molecules for communication among cells. They are characterized by natural targeting and low immunogenicity, and are mostly absorbed by cells through the paracrine pathway of mesenchymal stem cells. Moreover, they participate in the regulation and promotion of cell or tissue regeneration. As a scaffold material in regenerative medicine, hydrogel has good biocompatibility and degradability. Combining the two compounds can not only improve the retention time of exosomes at the lesion site, but also improve the dose of exosomes reaching the lesion site by in situ injection, and the therapeutic effect in the lesion area is significant and continuous. This paper summarizes the research results of the interaction of exocrine and hydrogel composite materials to promote tissue repair and regeneration, in order to facilitate research in the field of tissue regeneration in the future.
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