化学
联氨(抗抑郁剂)
偶联反应
功能群
胺气处理
格式化
金属
碘
有机化学
反应条件
组合化学
药物化学
催化作用
色谱法
聚合物
作者
Jing Long,Keyume Ablajan
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-05-22
卷期号:55 (19): 3113-3120
摘要
Abstract We have developed a new method for the synthesis of carbamates from amine and hydrazine formate. The reaction occurs in the presence of iodine and tert-butyl hydroperoxide, in which carbazates are produced via alkoxycarbonyl radical formation for cross-coupling reaction. The method exhibits broad functional group tolerance and affords a series of N-phenylcarbamates in moderate to good yields. Remarkably, our approach is metal free and utilizes cheap, readily available raw materials and relatively universal substrates.
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