基底外侧杏仁核
扁桃形结构
编码(内存)
心理学
多巴胺
身份(音乐)
神经科学
认知心理学
艺术
美学
作者
Ana C. Sias,Yousif Jafar,Caitlin M Goodpaster,Kathia Ramírez-Armenta,Tyler M Wrenn,Nicholas K. Griffin,Kamal Patel,Alexander Lamparelli,Melissa J. Sharpe,Kate M. Wassum
标识
DOI:10.1101/2022.09.26.509602
摘要
ABSTRACT To make adaptive decisions, we build an internal model of the associative relationships in an environment and use it to make predictions and inferences about specific available outcomes. Detailed, identity-specific cue-reward memories are a core feature of such cognitive maps. Here we used fiber photometry, cell-type and pathway-specific optogenetic manipulation, Pavlovian cue-reward conditioning, and decision-making tests in male and female rats, to reveal that ventral tegmental area dopamine (VTA DA ) projections to the basolateral amygdala (BLA) drive the encoding of identity-specific cue-reward memories. Dopamine is released in the BLA during cue-reward pairing and VTA DA →BLA activity is necessary and sufficient to link the identifying features of a reward to a predictive cue, but does not assign general incentive properties to the cue or mediate reinforcement. These data reveal a dopaminergic pathway for the learning that supports adaptive decision making and help explain how VTA DA neurons achieve their emerging multifaceted role in learning.
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