载脂蛋白E
疾病
风险因素
等位基因
阿尔茨海默病
心理学
民族
四分之一(加拿大硬币)
神经科学
老年学
医学
遗传学
生物
基因
病理
历史
社会学
考古
人类学
作者
Michaël E. Belloy,Valerio Napolioni,Michael D. Greicius
出处
期刊:Neuron
[Elsevier]
日期:2019-03-01
卷期号:101 (5): 820-838
被引量:321
标识
DOI:10.1016/j.neuron.2019.01.056
摘要
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however, by lingering uncertainty over how to treat the quasi "monogenic" role of apolipoprotein E (APOE). The APOE4 allele is not only the strongest genetic risk factor for AD, it also affects risk for cardiovascular disease, stroke, and other neurodegenerative disorders. This review, based mostly on data from human studies, ranges across a variety of APOE-related pathologies, touching on evolutionary genetics and risk mitigation by ethnicity and sex. The authors also address one of the most fundamental question pertaining to APOE4 and AD: does APOE4 increase AD risk via a loss or gain of function? The answer will be of the utmost importance in guiding future research in AD.
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