钠通道
止痛药
蝎子
蝎子毒素
医学
蝎子毒
化学
神经科学
毒液
重症监护医学
钠
生物信息学
药理学
生物
生物化学
有机化学
作者
Yijia Xu,Junbo Sun,Hongyu Liu,Jin Sun,Yue Yu,Yang Su,Yong Cui,Ming Zhao,Jinghai Zhang
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2018-12-28
卷期号:19 (11): 848-855
被引量:11
标识
DOI:10.2174/1389201019666181105160744
摘要
Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development. Keywords: Pain, VGSC, peptide, scorpion toxin, autoimmune diseases, NSAIDs.
科研通智能强力驱动
Strongly Powered by AbleSci AI