Plasma pharmacokinetics of isorhapontigenin, a novel derivative of stilbenes, in mice by LC-MS/MS method

Isorhapontigenin (ISO), a novel derivative of stilbene compound, possessess good pharmacological activities such as antiviral, antioxidant, and anticancer. The purpose of this study is to investigate the pharmacokinetic of ISO in mice plasma, after oral administration of three doses (40, 80, and 160 mg/kg). Isorhapontigenin was detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and a reliable LC-MS/MS assay for ISO in mice plasma was developed. The method was linear over a concentration range of 5-2000 ng/ml, and the lower limit of quantification was 5 ng/ml. The results indicated that there was a linear relationship between AUC(0-t), AUC(0-∞), and Cmax of ISO and dosages. ISO underwent quick absorption and elimination in mice.