Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications

Modification of Hyaluronic acid (HA) with Sodium metaperiodate (NaIO4) results in the formation of oxidized HA (OHA). OHA containing multiple aldehyde groups can easily react with the materials having amino functionality via formation of Schiff base linkage, resulting in the formation of OHA based hydrogel scaffolds. These hydrogels have recently attracted considerable attention as scaffolds for tissue engineering (TE) applications. Thus, the aim of the present review is to give an overview on OHA based hydrogels as scaffolds and their potential application in the field of TE along with the method of synthesis and important properties of OHA.