神经保护
神经营养素
神经营养因子
血管内皮生长因子
睫状神经营养因子
血管生成素
神经突
血管生成
炎症
神经生长因子
PI3K/AKT/mTOR通路
药理学
神经科学
医学
信号转导
受体
化学
生物
免疫学
内科学
细胞生物学
血管内皮生长因子受体
生物化学
体外
作者
Jian Yin,Ge Gong,Xinhui Liu
出处
期刊:Neuroscience
[Elsevier]
日期:2019-07-01
卷期号:411: 177-184
被引量:14
标识
DOI:10.1016/j.neuroscience.2019.05.038
摘要
Angiopoietin (Ang) is an angiogenic factor, but its neuroprotective and neurotrophic effects have recently come to light. Ang exerts neuroprotective effects by inhibiting neuronal apoptosis, protecting the blood-brain/blood-spinal cord barrier, reducing inflammation and promoting neovascularization. In addition, Ang can also promote neural development and neurite outgrowth via activation of the PI3K/Akt signaling pathway and binding to the Tie2 receptor and/or integrin receptor. In addition, Ang and vascular endothelial growth factor (VEGF) are known to interact in blood vessels in the nervous system and the combination of Ang and VEGF can mitigate the negative effects of VEGF, such as inflammation and local edema. These data indicated that Ang is a novel neuroprotective/neurotrophic factor, which may become a new tool for the treatment of nerve injury.
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