Synthesis of Quinolyl- and Isoquinolyl Heteroarylamines Using Palladium Catalyzed Suzuki Cross-Coupling Reaction

Quinolyl-and isoquinolylboronic acids are prepared from 5-bromoquinoline and 5-bromoisoquinoline, respectively, via halogen-metal exchange.Suzuki cross-coupling of these compounds with haloheteroarylamine leading to the corresponding heteroarylamine derivatives is described.