胰腺癌
癌症研究
癌相关成纤维细胞
信号转导
肿瘤微环境
胰腺导管腺癌
癌症
腺癌
生物
成纤维细胞
医学
细胞生物学
内科学
细胞培养
肿瘤细胞
遗传学
作者
Jianhua Ling,Paul J. Chiao
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2019-02-01
卷期号:9 (2): 173-175
被引量:12
标识
DOI:10.1158/2159-8290.cd-18-1460
摘要
Abstract Summary: In this issue of Cancer Discovery, Biffi and colleagues report that IL1 signaling cascades resulted in JAK/STAT activation and promoted an inflammatory cancer-associated fibroblast (iCAF) state, which contributed to the establishment of distinct fibroblast niches in the pancreatic ductal adenocarcinoma (PDAC) microenvironment to support the growth of PDAC cells. Furthermore, the investigators demonstrated that TGFβ signaling inhibited IL1R1 expression, antagonized IL1α responses, and promoted differentiation of CAFs into myofibroblasts; thus, IL1α signaling is an important therapeutic target for both PDAC cells and the iCAFs in the tumor microenvironment. See related article by Biffi et al. p. 282.
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