Objective: To determine the effect of bio-immunological medicine,interferon-α,in the treatment of advanced renal cell cancer after radical nephrectomy.Methods: The data of 47 cases of renal cell carcinoma at advanced stage treated with interferon-α after radical nephrectomy were reviewed and the outcomes were followed.Results: The total response rate of interferon-α was 66.0%.Conclusion: Interferon-α adminstration after radical nephrectomy is effective for the treatment of advance renal cell cancer by enhancing immune function and anti-tumor capability.