The paper discusses the results of using plasmapheresis in the multimodality treatment of 51 patients with Stage II hypertensive disease. It has been found that the application of plasmapheresis results in the patient's clinical improvement as attenuation of headache and giddiness, cessation of cardialgia and better general condition. After plasmapheresis treatment, a dosage of antihypertensive agents could be reduced in most patients. The findings suggest that plasmapheresis opens up new fields of use in the treatment of hypertensives, exerting a substantial effect on immunological and hemorheological parameters and making the baseline changed hemodynamic parameters normal.