微循环
尼卡地平
医学
血管舒张
脑动脉
微血管
脑循环
泌尿系统
颈内动脉
病理
麻醉
化学
内科学
血管生成
血压
作者
Hitoshi Nagano,Takahisa Suzuki,Michiyo Hayashi,Masaharu Asano
出处
期刊:PubMed
日期:1992-09-01
卷期号:6 (5): 497-502
被引量:5
摘要
The pharmacological effects of a human urinary kininogenase (SK-827) on the cerebral microcirculation were studied intravital-microscopically in a rabbit with cerebral microvessel injury induced by glass bead injection into an internal carotid artery. Intravenous administration of SK-827 dilated pial arteries of the brain and increased cerebral hemoglobin content (IHb). SK-827 tended to dilate smaller arterioles more markedly than larger arterioles, and larger arterioles than small arteries. SK-827 appeared to have a vasodilating effects qualitatively different from those of nicardipine and CDP-choline. Findings obtained by concurrent hematological and biochemical examinations also suggested its beneficial effects on the function of platelets and erythrocytes.
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