Distribution and pharmacokinetics of Gd-DTPA liposomes in mice

Objective To study the distribution and pharmacokinetics of Gd-DTPA and Lip Gd-DTPA in mice.Methods The tissue and blood concentration of Gd-DTPA and Lip Gd-DTPA in mice were determined by ICP-AES.Results The concentration time curves of them in mice could be fitted to two compartment open models.LipGd-DTPA maintained a higher level of blood drug concentration compared with that of Gd-DTPA,and the distribution of it in the liver and spleen were enhanced evidently.Conclusion LipGd-DTPA has targeting to the liver and spleen evidently.