Double Asymmetric Induction During the Addition of (RP)‐Menthyl Phenyl Phosphine Oxide to Chiral Aldimines

Abstract P , C ‐Stereogenic α‐amino phosphine oxides were prepared from the addition of ( R P )‐menthyl phenyl phosphine oxide to chiral aldimines under neat condition at 80 °C in up to 91:9 dr C and 99% yields. The diastereoselectivity was mainly induced by chiral phosphorus that showed matched or mismatched induction with ( S )‐ or ( R )‐aldimines, respectively. Chirality 28:132–135, 2016 . © 2015 Wiley Periodicals, Inc.