The protective effect of Salidroside on cor pulmonale rats induced by chronic hypoxia in normal pressure

Objective: To study the protective effect and mechanism of Salidroside on cor pulmonale rats induced by chronic hypoxia in normal pressure.Methods: Fifty Sprague-Dawley rats were randomly divided into five groups:normal control group,normal pressure hypoxia group,hypoxia+Salidroside group(low dose,median dose,high dose).Pulmonary arterial pressure(mPAP),Pulmonary arteriole micromorphometric index:WA/TA(vessel well area/total area)、SMC(density of medial smooth muscle cell) and PAMT(media thickness of pulmonary arterioles),weight ratio of right ventricle to left ventricle plus septum[RV/(LV+S)],CollagenⅠand Ⅲ were measured.Results: mPAP,RV/(LV+S),Ⅰtype collagen,arteriole micromorphometric index were significantly higher in rats of hypoxia group than those of control group.Salidroside could reverse the changes mentioned above.But there was no significant difference in content of Ⅲ type collagen in five groups Conclusions Salidroside can reduce pulmonary hypertension and pulmonary vessel remodeling induced by hypoxia through inhibiting proliferation of collagenⅠ.