Curative effect observation of concurrent chemoradiotherapy before colorectal cancer surgery

Objective To observe the curative effect and prognosis of concurrent chemoradiotherapy before colorectal cancer surgery.Methods 80 patients with rectal cancer from February 2010 to February 2011 in Central Hospital of Jinhua City were selected and divided into experimental group and control group with 40 cases in each group.Experimental group was treated with concurrent chemoradiotherapy before colorectal cancer surgery;control group was treated without concurrent chemoradiotherapy before colorectal cancer surgery and with adjuvant radiation and chemotherapy after the surgery.Colorectal cancer relegation before and after the surgery,the anus function after the surgery were compared between the two groups;RECIST evaluation result after the surgery between the two groups were compared;recurrence and quality of life between the two groups after 24 months' follow-up visit were compared.Results ①The proportion of T3,T4,N1 in experimental group after the chemoradiotherapy were lower than those before the chemoradiotherapy,the proportion of T3,T4,N1 in experimental group after the chemoradiotherapy were higher than those before the chemoradiotherapy,the differences were statistically significant(P 0.05).②The proportion of C level of anal function in experimental group after the operation was higher than that in control group,the difference was statistically significant(P 0.05).③CR,PR,total effective rate in experimental group [32.5%(13/40),52.5%(21/40),85.0%(34/40)] were all higher than those in control group [5.0%(2/40),25.0%(10/40),30.0%(12/40)],the differences were statistically significant(P 0.05).④No recurrence ratio in experimental group [90.0%(36/40)] was higher than that in control group [62.5%(25/40)],recurrence ratio in experimental group was lower than that in control group,the differences were statistically significant(P 0.05);the rate of excellent quality of life in experimental group [42.5%(17/40)] was higher than that in control group [15.0%(6/40)],the rate of poor quality of life in experimental group was lower than in control group,the differences were statistically significant(P 0.05).Conclusion Adopting chemoradiotherapy to rectal cancer patients before rectal cancer surgery has positive influence on their prognosis,it can improve treatment effective rate and reduce postoperative recurrence rate,and can also improve patients' postoperative life quality.